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As the human and mouse genomes are analyzed an increasing number of genes are found to have alternative non-coding first exons [26].
Substitution rates of SRF and MEF2A-D genes in the human and mouse genomes are presented in Figure 2. From the figure, mSRF (referred to as SRF in mice) evolves faster than its corresponding orthologous hSRF (referred to as SRF in humans).
Finally, the human and mouse genomes are estimated to contain approximately 25,000 genes.
Dr. Joel Schick began his presentation with the statement that human and mouse genomes are highly conserved and comprise approximately 20,000 coding genes.
Those CpG dinucleotides that remain aligned in human and mouse genomes are likely to be stabilized by selection pressure of a different nature.
Moreover, it was found [ 9] that the six RP pseudogenes shared at syntenic loci between the human and the mouse genomes are more conserved than other RP pseudogenes.
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Poly(A) sites in human and mouse genomes were obtained from PolyA_DB [55].
The limit of detection for mouse genomes was three haploid genomes per reaction.
Furthermore, homologous promoter sequences between human and mouse genomes were analyzed using the BLAST program [ 25].
Repetitive sequences (chrN_rmsk tables) in the human and mouse genomes were obtained from the UCSC database.
The transcript information for human and mouse genomes was extracted from ASTD [ 1, 2].
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