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Unfortunately, despite the completion of the human, rat and mouse genome sequencing projects, accurate and stable gene annotation information is not available.
Mice are the preferred species for genetic manipulation because of their genetic tractability and because mice carry 99% of the same genes as humans (Mouse Genome Sequencing et al., 2002).
It was estimated that the M. musculus B6 strain, for which the whole-genome sequences are available, has about 60 copies of an Sp100-rs gene, but this genomic portion is unassembled (Mouse Genome Sequencing Consortium 2002).
The Mouse Genome Sequencing Consortium undertook the multimillion dollar task of decoding the 2,500 million units of DNA in the mouse genome.
By the 1700's, mouse fanciers in Japan and China had domesticated many varieties of mice, mostly from musculus and domesticus, and Europeans later imported them, according to an article last week in Nature by the Mouse Genome Sequencing Consortium.
That is the strain of laboratory mouse whose genome sequence has just been published.The international mouse genome sequencing consortium and allied groups present their work in a bevy of papers in this week's issue of Nature.
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Each transcript was aligned to the Celera mouse genome sequenced to define the exon structure [ 30].
Inbred C57BL/6J mice are widely used in biological and biomedical research and for this reason the strain was selected to be the first mouse genome sequenced by a public consortium (Waterston et al. 2002).
Genomic sequences were also retrieved from the mouse genome sequence as reported in the NCBI 37 July 2007 assembly (UCSC Genome Browser).
Genomic coordinates of extended human gene loci were transferred to the mouse genome sequence using the UCSC Lift Genome Annotations tool (http://genome.ucsc.edu/cgi-bin/hgLiftOver).
Just as comparing the human and mouse genome sequences provides important clues about gene function, so, too, does comparing the DNA sequence among people.
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