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Information such as the names and binding promoters (in mouse genome) of these 23 TFs are listed in Tables 2 and 3, with more detailed information available from http://www.probtf.org/.
Based on this mutation rate, a size of the mouse genome of approximately 2.5×103 Mbp and assuming that approximately 1.5% of the genome encodes a protein, we anticipate that each G1 founder contains about 25 mutations that affect protein sequence.
In comparison, the human genome consists of 45% and the mouse genome of 38% transposable elements [ 17, 18].
MusD is a LTR retrotransposon with approximately 100 copies in the mouse genome, of which three are believed to be active.
We have compared the effective gene coverage in the mouse genome of different commercial and noncommercial oligonucleotide microarray platforms by performing an in-house gene annotation of probes.
To evaluate the gene order of preferentially expressed genes in testis and to eliminate the effect of tandem duplications we purged the whole mouse genome of tandemly duplicated genes (see Methods).
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We identified frequent retrotransposition in both the human and mouse genomes of a single orthologous gene in each gene family encoding glycolytic enzymes.
We illustrated the utility of this method by rapid and systematic screening of mouse genome for reprogramming factors.
He added that he was switching his 300 sequencing machines to analysis of the mouse genome, knowledge of which will help researchers interpret what human genes do.
Around 40percentt of the mouse genome consists of RTE sequence, slightly lower than observed for the human genome, although this presumably is a result of the higher substitution rate in mouse, limiting the identification of old RTE sequence [ 12, 13].
The gene family encoding the monomeric MUPs consists of at least 40 42 genes (there are still gaps in this region of the mouse genome), half of which are pseudogenes.
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