Sentence examples for mouse genome including from inspiring English sources
Moreover, we generated isoform signatures for all gene isoforms in the human and mouse genome, including both known and computationally predicted ones.
In QSCs, nearly 50% of annotated genes in the mouse genome, including nearly all housekeeping genes and cell-cycle genes, were marked with H3K4me3 at their TSSs.
The International Mouse Phenotyping Consortium is coordinating efforts to phenotype single gene knockouts covering the entire mouse genome, including characterising developmental defects for those knockout lines that prove to be embryonic lethal.
For ectopic expression, several techniques can be used to introduce novel genetic sequences into the mouse genome, including homologous recombination into a specific locus in the mouse genome, or random integration of transgenes through injection into an embryo.
Gene targeting in embryonic stem (ES) cells allows virtually unrestricted manipulation of the mouse genome, including the engineering of large segmental aneuploidies (Liu et al, 1998; Ramirez-Solis et al, 1995) and many pathologies relevant to human disease can be induced in the mouse using environmental, pharmacological or genetic sensitization protocols.
The mouse genome includes caspase-1, -11, and -12, whereas the human and chimp genomes contain caspase-1, -4, -5, and -12, with caspase-12 typically inactivated in the human genome.
The sequencing of several mouse genomes, including that of the widely used C57BL/6 strain, motivated the development of a resource to elucidate gene function.
In contrast to the evidence from human [ 1] and bank vole, annotations of various rodent mt genome sequences in GenBank (including the reference mouse mt genome) include complete TAG stop codons in the CDS of both nad1 and nad2 that overlap the downstream trnI and trnW by 2 bp (AG) in each case (Fig. 1).
Recent advances triggered by the invention of chromatin conformation capture (3C) enable ascertainment of genome architecture on a genome-wide scale for virtually any genome, including human [ 4- 6], mouse [ 5, 7], budding yeast [ 8], bacteria [ 9], fruit fly [ 10] and a malarial parasite [ 11].
A current listing from the Mouse Genome Database includes 251 genetically determined mouse ocular phenotypes, a number that increases daily.
Tandemly repeated DNA represents a significant portion of the mouse genome and include centromere and pericentromere regions.
