The CCGG sites are distributed almost evenly over the mouse genome and do not show an apparent bias to a particular genomic context.
Zhang, Y. et al. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations.
The consortium, however, is also working on the mouse genome and intends to put that and other important tools for interpreting the human genome in the public domain.
Here, we screened the mouse genome, and found that tryptophan hydroxylase (TPH) is implicated in the maturation of sensorimotor gating.
Using genetic engineering, researchers incorporate a gene that codes for the protein into the mouse genome and fuse the glowing protein with synaptic molecules.
Here we map the genome-wide localization of lamin B1 in an euchromatin-enriched fraction of the mouse genome and follow its dynamics during the epithelial-to-mesenchymal transition (EMT).
Mouse ENCODE analyzed more than 100 mouse cell types and tissues to annotate the regulatory elements of the mouse genome and compare them to the regulatory elements in the human genome.
Celera's president, Dr. J. Craig Venter, said that he would draw the DNA from three strains of mouse, to study the natural variation of the mouse genome, and that he would assemble a "humanized mouse genome," one with the genes arranged in the same order as their counterparts on the human genome instead of in the natural mouse order.
The sequencing of the mouse genome and more recent re-sequencing of numerous inbred mouse strains have further cemented the status of mice as the premier mammalian organism for genetic studies.
This article provides data supporting the presence and location of HPRT1 pseudogenes within human and mouse genome, and the strategies used for designing primers that avoid the co-amplification of contaminating pseudogenes in qRT-PCR.
Now, in four papers published in this issue4,5,6,7, the Mouse ENCODE Consortium presents data sets that dramatically enhance our understanding of the regulation of the mouse genome, and of the similarities and differences compared with the human genome.
