Pivotal studies are presented in more detail to demonstrate the use of the new methods: the in vivo investigation of bacterial virulence factors and host interaction in a human colonization protocol; the experimental mouse UTI model where mice strains differing in genetics demonstrate selective dysfunctions; the search for human polymorphism explaining suceptibility to infectious diseases.
Using elegant mouse genetics, he demonstrated that some target(s) of phosphatidylinositol 3-kinase, other than Akt, are required for pulmonary metastasis of MMTV PyMT tumors.
Analysis of the Map3k1 PHD by mouse genetics has also demonstrated that, like the Map3k1 kinase domain, the PHD motif is important for lymphocyte T-cell receptor signaling, cardiac tissue damage and stem cells.
Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 regulathe the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies.
Reviewer 1: This is a short straightforward report that uses mouse genetics, anatomical colocalization and physiology and pharmacology in brain slices to demonstrate that most forebrain cholinergic neurons are also GABAergic.
Comprehensive knowledge of mouse genetics and availability of numerous genetically modified mouse models more than any other models.
The advanced knowledge of mouse genetics and the availability of numerous genetically modified mouse models greatly facilitate functional studies.
Since many genetically engineered mice have the B6 genetic background, this sensitivity poses a major obstacle to studies of mouse genetics.
"For the basic research, it was the conquest of mouse genetics," he says.
At Bar Harbor, Snell, who was already immersed in mouse genetics, began to focus on the genetics of transplantation.
