Sentence examples for mouse genetic data from inspiring English sources
Mouse genetic data allow one to make the functional connection between cohesin subunits, axial elements' structure, and genetic recombination itself.
Our mouse genetic data strongly suggest that MELK is not essential in mice and deserves attention as a target for therapeutic development.
The mouse genetic data complements the human and the use of GWAS in HS mice promises to deliver more candidate genes.
Together the mouse genetic data reported in Haley et al. provide the rationale for the use of targeted IGF1-receptor antagonists to treat both tumours with IGF2 LOI and/or p53 inactivating mutations in future clinical trials.
These data are in agreement with previous mouse genetic data obtained with KO technology; embryogenesis was stopped very early, with cells affected by severe defects in S-phase progression.
Furthermore, this approach of integrating mouse genetic mapping data of evolutionary conserved phenotypes may also proof useful for a wide variety of complex human diseases, such as congenital heart disease, eating disorders, and autism spectrum disorders.
To this end, we first analyzed mouse and human genetic data identifying a candidate gene putatively involved in ethanol response in both species.
We first use a novel cross-species, comparative analysis using mouse and human genetic data to identify a candidate gene, MGST3, associated with adult hippocampus size in both systems.
Consistent with the genetic data, mouse models with activating KRAS mutations combined with p53 or DPC4 deletion exhibited accelerated PDAC development, supporting the idea of a complex synergistic pro-tumor effect involving the alteration of both oncogenes and tumor suppressor genes.
Extensive genetic data from mouse models and human cancers have demonstrated a role for adherens junctions in suppressing cancer progression [ 10], and reduced expression of adherens junction proteins is often associated with poor clinical outcome for cancer patients [ 11- 15].
The network was constructed from gene expression and genetic data from nine different mouse F2 crosses encompassing >3,000 mice and nine different mouse strains.
