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MeSHOPs could be explored for gene-disease associations in other species than human - preliminary analysis predicting mouse genes associated with MeSH disease terms have achieved similar performance results.
In the phenotypic-centric approach, the expected concordance for a given phenotype X was calculated as: [(number of mouse genes associated with X) * (number of human genes associated with X)/ total number of ortholog pairs with available mouse models)].
In this approach, we mapped the human phenotypes associated with GWAS-discovered loci to their corresponding mouse phenotypes, and we assembled a comprehensive list of mouse genes associated with these phenotypes.
The second set consists of 764 mouse genes associated with "postnatal lethality" after removal of genes overlapping the cancer set.
The enrichment of InterPro domains (http://www.ebi.ac.uk/interpro/) of human and mouse genes associated with HCNSs was determined by Fisher's exact test.
We next used our matched arrays to identify mouse cell cycle genes as well as mouse genes associated with genes implicated in human diabetes.
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In susceptible mice relative to resistant mice, genes associated with EBOV infection were differentially induced.
In adipose tissue of DDAH mice, genes characteristic of differentiated adipocytes were down-regulated, whereas in eNOS-/ mice, genes associated with adipogenesis, fatty acid and triglyceride synthesis were upregulated.
This could account for the finding that there are very few mouse miRNA genes associated with CNVs, and indicates a significant difference between human and mouse miRNAs.
Moreover, a genome-wide association study of obesity in mice identified genes associated with obesity in mice that overlap with some genes involved in human obesity (Parks et al., 2013).
In RXRα hepatocyte-deficient mice, many genes associated with cell growth had changes in their mRNA levels.
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