"You have to put the human stuttering mutations in the mouse genes and we've done that.
New Interplays Between Mouse Genes and Behavior 26 38 (Society for Neuroscience, Washington D.C., 1996).
It has lists of known mouse genes and reports of nomenclature committees on how to refer correctly to mouse strains.
To make a mouse, in other words, scientists can now see that evolution took the generic recipe of mammal-making genes, sprinkled in just a dash of special-purpose mouse genes and eek! -- another wonderfully designed organism from nature's magic cookbook.
Lexicon, for example, is analysing 5,000 mouse genes and studying the physiology and behaviour of mice to discover novel drug targets in a number of areas, including cognitive and neurodegenerative disorders.
Their dataset was comprised of over 1,500 mouse genes and their human orthologs that are expressed in over 26 stages of embryonic development.
We currently produce DNA microarrays representing the yeast, mouse, and human genomes (the yeast microarray has over 6000 yeast genes, the mouse microarray has over 15,000 mouse genes, and the two human microarrays have 1700 genes and over 19,000 genes).
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For GenAge associations we used only mouse genes and mouse orthologs of human genes listed in GenAge.
To explore the evolution of ASEs, we had further explored connection between NAS mouse genes and their alternatively spliced human orthologs.
The first intron is substantially longer, with respect to the other introns, in most human and mouse genes and shows higher rate of TE insertion [39].
