Sentence examples for mouse gene knockouts from inspiring English sources

About 15% of mouse gene knockouts are lethal; others produce unexpected handicaps.

Because most of the mouse gene knockouts were generated by individual laboratories for finding knockout phenotypes, recently duplicated genes may have been purposely avoided to minimize the experimental cost due to negative-phenotype results.

Mouse gene knockouts prepared for TSP-1, TSP-2, TSP-3, and TSP-5 have demonstrated distinct roles for these family members in normal tissue development and/or adult physiology and pathology [ 7- 10].

Controversial issues such as publication bias or study size which confound human genetic association studies are not as relevant here in the context of studies of experimentally determined individual mouse gene knockouts and related studies.

Substitution rates between mouse and rat orthologs suggested that essential genes were slower evolving, but no difference was observed after controlling for fast-evolving immunity genes (Hurst and Smith 1999), whereas greater sampling of mouse gene knockouts did identify an impact of gene essentiality on the rate of protein sequence evolution (Liao et al. 2006).

Experience gained over more than a decade of mouse transgenics work has revealed that approximately half of all mouse gene knockouts demonstrating recessive EP lethality complete the major period of organogenesis (E14.5 E15.5) and reach a point when organ arrangement resembles that of the adult.

Recent progress in human genome wide association studies in combination with high-throughput mouse gene knockout phenotyping efforts of multiple genes and advanced conditional gene inactivation in mouse models have successfully identified genes with crucial roles in cortical bone homeostasis.

In the mouse gene knockout model IL-6 has also been shown to participate in the early induction of IFN γ production [23].

Mouse gene knockout studies indicate that all four CatSper subunits are required to mediate functional Ca2+-selective sperm currents necessary for sperm hyperactivation [12] [14], [21].

The apparent difference between the mouse gene knockout and zebrafish models suggests that important aspects of the Prion protein biology may be revealed in the zebrafish model, using morpholino (MO) mediated translation blocking [10].

Lexicon Pharmaceuticals, during the decade preceding the initiation of the IKMC program, successfully employed industrialized biology to generate and phenotype over 4 650 mouse gene knockout lines.