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A recent experimental study of adult mouse forebrain reported the expression of miRNAs in synaptoneurosomes (SYN), a synaptic fraction that is enriched in pinched-off dendritic spines [ 10].
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Our previous study in adult mouse forebrain [ 10] reported that the sets of microRNAs that are enriched vs. depleted in synaptic fractions differ significantly in their tissue expression patterns, evolutionary histories, and overall expression levels.
Here, using both population-based and single cell transcriptome analyses of young and aged mouse forebrain ependymal and subependymal regions and comprehensive "big-data" processing, we report that NSC/NPCs reside in a rather inflammatory environment in aged brain, which likely contributes to the differentiation bias towards astrocytes versus neurons.
This conserved sequence is able to drive reporter expression in the mouse forebrain [ 11, 18, 27].
Recently, we reported that both WEP and EEP displayed antioxidant actions against lipid peroxidation in mouse forebrain homogenates and against the diphenyl- p-picrylhydrazyl (DPPH) radical [ 16].
Open image in new window Figure 2 Reduced cell proliferation and neurogenesis in aged mouse forebrain neurogenic zone.
RNA was extracted from mouse forebrain using Trizol.
Here we present a new method for the efficient introduction of nucleic acids into the postnatal mouse forebrain.
Taken together, these results demonstrate that chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.
We present evidence that Oto/PGAP1 functions as a novel component of the Wnt pathway during mouse forebrain development.
We used GeneSpring to identify significantly overrepresented Gene Ontology (GO) categories in the Atrx-null mouse forebrain.
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