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However, Dicer ablation in the mouse forebrain led to increased cell death in committed neuronal progenitors (De Pietri Tonelli et al., 2008), and miR-24a is required to prevent apoptosis in the retina (Walker and Harland, 2009).
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Inactivation of Atrx in the developing mouse forebrain leads to reduced forebrain size, hippocampal dysgenesis, genomic instability, and elevated p53-dependent neuronal apoptosis (Bérubé et al., 2005; Seah et al., 2008; Watson et al., 2013).
In Tau mice, the overexpression of a mutated version (P301L) of the human tau gene restricted in the forebrain leads to age-dependent spatial memory deficits, tau neurofibrillary tangles, and neuronal loss.
We used GeneSpring to identify significantly overrepresented Gene Ontology (GO) categories in the Atrx-null mouse forebrain.
Open image in new window Figure 2 Reduced cell proliferation and neurogenesis in aged mouse forebrain neurogenic zone.
In the present study, we describe a simple model of mouse forebrain ischemia where the bilateral common carotid artery occlusion (BCCO) is combined with isoflurane-induced hypotension.
RNA was extracted from mouse forebrain using Trizol.
Here we present a new method for the efficient introduction of nucleic acids into the postnatal mouse forebrain.
Taken together, these results demonstrate that chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.
We present evidence that Oto/PGAP1 functions as a novel component of the Wnt pathway during mouse forebrain development.
This conserved sequence is able to drive reporter expression in the mouse forebrain [ 11, 18, 27].
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