Exact(2)
The Apoe−/− mouse fed a high fat diet is an established model of atherogenesis.
For comparison, plasma from an Ldlr −/− mouse fed a 60% high-fat diet showed a plasma lipoprotein profile similar to the apoc2 mutant, although it had lower TG levels.
Similar(56)
18F-BMS PET scans were performed on control mice, rotenone-injected mice, and mice fed a MCD diet.
And a group of mice fed a high-protein diet had different gut microbes and better memory skills than mice fed a typical diet.
MC-1 activity was decreased by 12% (p < 0.05) in mice fed a MCD diet for 1 week and by 27% (p < 0.01) in mice fed a MCD diet for 2 weeks compared with the control group (Fig. 3).
ApoE-null mice fed a chow diet supplemented with TMAO appear to have an enhanced aortic lesion.
These effects were not observed in mice fed a 2 amino acids mix (glycine and glutamine).
Notably, MC-1 activity was also significantly decreased at 2 weeks in mice fed a MCD diet.
In mice fed a MCD diet for 2 weeks, mild steatosis and minimal inflammation were observed (Fig. 2, Table 1).
Control mice, rotenone-injected mice, and mice fed a MCD diet for 1 and 2 weeks were anesthetized with 2% isoflurane.
#p < 0.05, ##p < 0.01 compared with the control group that was fed a normal diet; *p < 0.05, **p < 0.01 compared with control mice fed a 45%% fat diet.
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