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The illustration depicts a wild type mouse and a littermate mutant mouse expressing a constitutive serine phosphorylation mutation in Fas-Associated Death Domain (FADD-D).
Tilly's study found that a bone-marrow transplant from a donor mouse expressing a green fluorescent marker called GFP in all its cells resulted in green eggs — presumably newly generated — in the ovary of a normal mouse recipient.
We recently produced a line of knock-in mouse expressing a unique human-mouse chimeric PrP (Ki-ChM mouse), which has mouse-specific residues practically only at the C-terminal part after posttranslational modification, and here we attempted transmission of various human prions to assess the susceptibility profile of the mouse.
To this end, we have engineered a transgenic mouse expressing a reporter (GFPμ) sensitive to perturbations in UPS function as demonstrated by Bence and colleagues [32].
However, our finding is consistent with a recent study by the Dantuma lab using a transgenic mouse expressing a different UPS reporter substrate [24].
To visualize IL-7 producing cells, we created a BAC transgenic mouse expressing a cyan fluorescent protein (ECFP) under the control of the Il7 promoter and any other cis regulatory elements contained in a BAC.
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Similarly, serum ALT, AST as well as hepatic inflammatory marker expression in db/db mice were each significantly elevated in db/db AAV8-Arg2 micexpressingng Ad-Rgs16 as compared with db/db AAV8-Arg2 Ad-Control littermates (Fig. 10c, d).
Most of the CD8+ T cells in the transgenic 2C mouse express a T-cell receptor specific for the class I major histocompatibility complex Ld+ locus.
Sequence and functional analysis indicate that both human and mouse express a number of neutrophil-activating chemokines.
In that study, LKB1 floxed mice were crossed to mice expressing a RIP2-promoter driving Cre-recombinase expression.
High bone mass in mice expressing a mutant LRP5 gene.
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