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Dr. Varmus said the Gleevec trials and similar results from mouse experiments suggested that turning off a hyperactive signaling protein could be a general way of forcing cancer cells to trigger the self-destruct mechanism all cells possess.
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Suppose such drugs are developed and retard aging of the tissues in humans just as the mouse experiments suggest can be done.
Our HIS mouse experiments suggest that IL-7 can improve T cell levels even in the absence of antiretroviral drugs, and do so without boosting HIV titers.
The failure of the selective GABA-B-R agonist baclofen to inhibit xenograft growth in the mouse experiment suggested to us that chronic treatment with baclofen might have desensitized the GABA-B-Rs.
The second mouse experiment suggests that middle age would be an effective time for clinical intervention, assuming humans behave in the same way.
New results from mice experiments suggest that physical exercise can have a positive impact on GvHD.
However pantothenate biosynthesis knockouts in M. tuberculosis in mouse infection experiments suggest the operation of some salvage mechanism [ 79].
Moreover, the mouse model experiments suggest that the murine host-derived cytokine network replaces human-derived cytokines in stimulation of hormone-independent growth of MCF7S1 breast cancer cells.
Mouse 'knockout' experiments suggest that the VEGFR-1 plays a role in endothelial differentiation and/or interactions between the endothelium and extracellular matrix (Fong et al, 1995), whereas signalling through VEGFR-2 leads to endothelial cell proliferation and migration (Waltenberger et al, 1994).
After experiments suggested that mouse and human brain cells were failing to dispose of the aggregates, the researchers tried the equivalent of hiring more custodians.
We were able to do the in vitro experiments suggested by the reviewers with the mut- Stat3 mice, but we did not have mice for in vivo experiments where a large cohort of mice from the same sex is needed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com