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The two mouse experiments made "it very clear that that kind of antibody is protective," Dr. Fauci said.
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"Remember leptin," he says, a hormone that in initial experiments made fat mice thin.
In vivo experiments made in MyMRKO mice, but in the hypertensive model mediated by angiotensin II/L-NAME, did not show protection to develop hypertension but presented reduced signs of aortic fibrosis and hypertrophy.
In the case of sv129/Bl6 mice, males and females were investigated in independent experiments, making any statistical comparison unlikely.
Each experiment made in triplicate.
For survival experiments, mice were made neutropenic as previously described [48] and then injected with 7×107 CFUs of each of the strains studied.
The mouse experiments were a run-up to monkey experiments.
A similar procedure might be tried in people, he said, if the mouse experiments are promising.
But both scientists fault the mouse experiments.
All mouse experiments were done blindly.
Mouse experiments were repeated three times.
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