Suggestions(2)
Exact(4)
The study protocol MO08M334 "Evaluating vaginal microbicides in mice", which is specific for the mouse experiments described in this study, was approved by the Johns Hopkins University Animal Care and Use Committee (i.e. the Johns Hopkins Animal Ethics Committee) Chaired by Nancy A. Ator.
All mouse experiments described in this study were conducted according to the national (Belgian Law 14/08/1986 and 22/12/2003, Belgian Royal Decree 06/04/2010) and European (EU Directives 2010/63/EU, 86/609/EEG) animal regulations.
The mouse experiments described in this paper have been permitted by the Animal Care Committee of Rhineland-Palatinate (Koblenz, Germany) with the permit No. AZ 23 177-07/G 1231-043.
The growth of poxviruses in embyonated eggs and the mouse experiments described below were approved by the Animal Research Ethics Committee in the Faculty of Health Sciences, University of Cape Town.
Similar(56)
Possibly, similar mechanisms counteracted the expansion of gene-protected cells in the presence of ongoing virus replication in the mouse experiment described here.
A reduction in SOD1 activity is not causative for ALS (which is certainly what the mouse data show), however, it may modify disease, as suggested by results from the mouse cross experiments described above.
In contrast to Canault et al., and seemingly at variance with their findings with p55−/− mice, loss of TNF-α did not alter lesion development in female C57/BL6 mice in experiments described by Schreyer et al., while LTα deficiency resulted in a marked 62% reduction in lesion size.
Because of involvement of imprinting in the region, a specific breeding scheme diagramed in supplemental Figure S4 was followed to produce mice for experiments described below.
The diabetic (Akita/+) mice used in the experiments described here were male owing to effectiveness and severity of the diabetic phenotype in males.
Mouse Meis1 primers used in the experiments described yielded a 405 bp PCR product containing endogenous mouse Meis1 as well as human MEIS1 (nt 1115 1519 of NM_002398), resulting from the pcDNA4-encoded transgene.
Only male mice were used in the experiments described below.
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