The supernumerary tooth (S) has been hypothetically homologized to the premolar, which has disappeared during mouse evolution.
As all the Class B genes are almost identical to each other, researchers have concluded that these duplications occurred very recently in mouse evolution.
This indicates that there are several pathogenic human mutations that have become fixed in mouse evolution [ 43].
The large diastemal rudiments have been interpreted as rudimentary primordia of the premolars lost during mouse evolution (compare to Figs. 2 and 5).
The gain of splice forms has been shown to be a continuous process in human and mouse evolution [ 32], which certainly provides material for functional divergence.
Rock pocket mouse evolution is one of the most straightforward examples of evolutionary phenomena; it allows students to develop a model of evolution that includes but is not limited to the Hardy-Weinberg principle, genotypic mutation, and phenotypic trait expression.
A key question is whether these four gene families (Ssty1/2, Asty, Sly and Orly) were amplified separately on Yq during mouse evolution, or whether there was a single period of amplification increasing the copy number of all genes simultaneously.
The results of our phylogeographical analysis suggest that the requirement for hotspot diversity depends on geographical range and time span in mouse evolution, and that Prdm9 polymorphism has not been maintained by a simple balanced selection in the population of each subspecies.
Because such results could potentially be sensitive to the ortholog pairs compared, the quality of the gene models, and peculiarities of human/mouse evolution, we also repeated such analyses using a variety of other mammals [see Additional file 10].
This analysis will facilitate functional genomic analysis of Del36H and provides insights into mouse genome evolution.
Genome search and phylogenetic tree analysis is used to determine the order of events in mouse Yq evolution.
