Sentence examples for mouse epithelial subsets from inspiring English sources

Comparative analyses of normal mouse epithelial subsets with murine tumor models have implicated distinct cell types in contributing to tumorigenesis in the different models.

miRNAs that are differentially expressed between the mouse mammary epithelial subsets: MaSC/basal (MS), luminal progenitor (LP) and mature luminal (ML).

Furthermore, genome-wide transcriptome analyses [ 11, 12] of mouse mammary epithelial subsets have identified a number of potential regulators of mammary gland development.

Not only does the epigenome contribute to gene expression changes [ 14], but it tightly correlates with the miRNA expression profiles of the different mouse mammary epithelial subsets.

Although CD24 is expressed in all epithelial subsets in mouse mammary epithelium [ 3- 5], within human breast tissue, it marks luminal progenitor and mature luminal cells.

The mouse and human epithelial subset signatures were then subjected to Ingenuity Pathway Analysis (IPA) to identify conserved pathways.

Human NOTCH-4 was most highly expressed in the basal population, compatible with the findings of Raouf et al. [ 11] but differing from the mouse Notch-4 gene, which was expressed in all epithelial subsets at low levels [ 28].

Here we performed genome-wide transcriptome analyses of three different mouse epithelial subpopulations and established pathways that are conserved in functionally equivalent subsets in humans by using specific gene signatures.

The number of cells in each thymocyte subset is closer to that in the mouse epithelial network: 4.7% (419.8±42.4 cells) of DN cells, 84% (7559.4±128.8 cells) of DP cells, 11.4% (230.4±8.75 cells cells and 789.3±16.0 cells cells) of SP cells, and 0.9% (83.9±4.35 cells) of cells that are selected and leave the lattice.

Differential expression analysis comparing the stroma subset with the average of the three epithelial subsets revealed 276 miRNAs that distinguished stroma from the total epithelium in mouse (Additional file 1: Table S1; FDR <0.05) and 181 in human (Additional file 2: Table S2; FDR <0.05).

A differential expression analysis of the combined mouse and human expression profiles was conducted to find miRNAs that showed the same pattern of differential expression between the epithelial subsets in both species.