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Other knockouts have less severe defects or multiple gamete function defects (e.g., [74]), and mouse eggs deficient in Itga9 or Itgb1 do differ from wild-type eggs in their ability to support sperm binding [10], [22].
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Scientists have created mouse eggs from stem cells and used them to make healthy baby mice.
Wild-type mice and mice deficient in both murine GSTP genes (GstP1/P2) were treated with cisplatin.
I was interested in studying eggs NOT because I think anyone in America is egg deficient, but because I think nutritional epidemiology has a dangerous blind spot.
Mouse oocytes deficient in SENP7 experienced meiotic arrest at prophase I and metaphase I stages, causing a substantial decrease of mature eggs.
A mouse deficient for CAXIV was recently described [37].
Wt: control mice; A1: AMPdeficientent homozygous mice.
TERT-deficient mice and mTR-deficient mice were derived as previously described [ 28, 29].
The authors report that mice deficient in Cx3xr1 are protected from granuloma formation and hepatic injury induced by S. japonicum eggs, as manifested by a reduced loss of body weight, attenuated hepatomegaly and preservation of liver function.
When the mouse was Mest-deficient, it was a non-nurturing mouse.
Consequently, mice deficient in SUN4 display globozoospermia with associated infertility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com