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In fact, the later approach has demonstrated therapeutic relevance in a mouse disease model [9].
The use of bioluminescent imaging combined with a mouse disease model allowed us to investigate the progression of meningococcal sepsis over time.
By using a humanized mouse disease model, we show here that N. meningitidis can invade the meninges through the olfactory nerve system.
Using an intranasally challenged mouse disease model, we found that twenty percent of the mice developed lethal meningitis even though no bacteria could be detected in blood.
A mouse disease model driven by chronic exposure of the airway to whole house dust mite extract (HDM) has been developed to more accurately understand the dynamic pathophysiological mechanisms linking allergen-induced airway inflammation, structural changes and dysfunction.
This dose range was chosen to better define the therapeutic window within this mouse disease model.
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Mouse disease models have proven indispensable in glaucoma research, yet the complexity of the vast number of models and mouse strains has also led to confusing findings.
Many rare human inherited diseases remain untreatable despite the fact that the disease causing genes are known and adequate mouse disease models have been developed.
Administration of transforming growth factor-β (TGF-β) has been found to be of therapeutic benefit in various mouse disease models and has potential clinical usefulness.
FMRpolyG accumulates in ubiquitin-positive inclusions in Drosophila, cell culture, mouse disease models, and FXTAS patient brains.
These studies showed that BM cells could contribute to liver regeneration after partial hepatectomy (PHx) [3], and reduce liver fibrosis in mouse disease models [4], [5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com