This sexually dimorphic expression of Mro has been observed in two independent studies of mouse gonad development using quantitative RT-PCR [10] and DNA microarrays [11].
The protein profiling data is a time course study of protein expression levels with 6 time points, encompassing the protein data from early embryonic stage E13.5 through adulthood during ICR mouse lung development using gel-free two-dimensional liquid chromatography coupled to shotgun tandem mass spectrometry (MudPIT).
We computationally visualized the Waddington landscape of mouse preimplantation development using the experimental data and depicted the differentiation of cell lineages as bifurcations of the valleys.
Concerning the murine Wnt5 genes, the analysed expression data were also retrieved from the dataset browser of GEO database, [ 57] from microarray experiment during mice pancreatic development, using the Affymetrix Murine Genome U74 Version 2 array [ 58].
Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach.
We constructed the epigenetic landscape of mouse preimplantation embryonic development using the expression profiles of 48 genes – mostly TFs – in 442 single pre-implantation embryonic cells [ 8].
A main focus of our work is to define a novel function for NFkB in regulating postnatal lung development using mouse models and primary cell lines.
The lab has been examining conserved mechanisms of forebrain development using mouse models, and human-specific mechanisms by examining human stem and progenitor cells.
Extensive studies should focus on the mechanism of the oncogenic role of TAZ in breast cancer development using mouse model.
We investigated the role of loss of function of BRCA1 and p53 in ovarian cancer development using mouse models with conditionally expressed alleles of Brca1 and/or p53.
