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Specifically, one mouse developed a large palpable ovarian mass 132 days after bilateral Ad5-CMV-Cre injection, one mouse developed a small mass at the end of one of the uterine horns 373 days after unilateral injection of Ad5-CMV-Cre, and one control mouse developed a palpable subcutaneous mass located near the scapulae 353 days after PBS injection.
At the eighteen months follow-up after the gene transfer major consequences were seen; one mouse developed a hepatocellular carcinoma in the liver and another had a papillary adenocarcinoma in the lungs (Figure 6A, B).
This mouse developed a lump on its back at 25 weeks of age.
One mouse developed a 5 mm nodule by 15 months of age.
When a mouse developed a palpable tumor, it was randomly assigned to one of 4 groups.
In addition, two studies demonstrated that a compound Dok1/Dok2 knockout mouse developed a CML-like disease [ 61, 62].
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If, say, the mouse develops a disease, the indication is that the gene is related to the condition.
The mouse develops a developmentally and functionally distinct, non-canonical beige fat cell type as an adaptation to cold ambient temperature.
This mouse develops a patchy, chronic colitis similar to human Crohn's disease.
Within five months, 13 of the 30 mice developed a blood disease that mimicked human chronic myelogenous leukemia.
The normal mice developed a fatty liver and became resistant to insulin.
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