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They all induce mouse dendritic cell maturation and B cell proliferation.
Hsp70-VP22268–301, Hsp70-VP22268 301n, was efficienthe taken up by mouse dendritic cell (DC) line DC2.4.
When added to DC2.4 cells, a mouse dendritic cell line, the fusion protein containing polyhistidine of 25 residues was efficiently taken up by the cells and efficiently distributed to the cytosol.
In addition to the examples described in the previous reviews [ 14, 15], extended site mechanisms for binding biantennary N-linked glycans have recently been demonstrated for the mouse dendritic cell immunoreceptor 2 (DCIR2) and BDCA-2 [ 9, 10].
It is possible that activity in humans may be less than in mice, due to differences in TLR9 expression in human and mouse dendritic cell populations, although a number of studies have now shown that CpG are still active in higher species, including humans.
Interestingly, a recent study of mouse dendritic cell activation, which happens at a time-scale of many hours, similar to the G1-S transition, found that the vast majority of changes in protein synthesis were due to altered mRNA abundance, rather than due to changes in translation rates (Jovanovic et al., 2015).
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Montecalvo, A. et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
Winzler, C.et al. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures.
Pierre, P.et al. Developmental regulation of MHC class II transport in mouse dendritic cells.
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
Hsu, S. et al. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway.
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