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A mouse deficient for CAXIV was recently described [37].
Using a mouse deficient for the precursor of CLIP, CD74, we observed decreased peripheral lymphocyte activation, decreased neurodegeneration, and a significantly smaller lesion size following TBI.
PGF has been less studied than VEGF-A but it has been shown to play a critical role in vessel stabilization under pathological events [ 78], and recently Freitas-Andrade et al. developed a mouse deficient for Pigf[ 79].
Of particular interest is the murine model for Duchenne dystrophy (mdx) that does not display the severe myopathy seen in boys unless it is crossed to a mouse deficient for telomerase (Sacco et al, 2010).
Another example for redundancy during chondrogenesis is the mouse deficient for melanoma inhibitory activity/cartilage-derived, retinoic acid sensitive protein (MIA/CD-RAP), which also does not manifest strong abnormalities [ 31].
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We studied the kinetics of γ-H2AX chromatin foci removal after irradiation of mice deficient for HR and mice deficient for NHEJ.
In mice deficient for gelsolin, mammary gland architecture was unaltered at the histological level.
Moreover, mice deficient for miR-142 displayed an impairment of CD4+ cDC homeostasis both in vitro and in vivo.
Several recent studies have reported intriguing phenotypes of mice deficient for ERAD function in specific cell types.
We generated mice deficient for all six Gbp genes located on chromosome 3 (Gbychr3) by targeted chromosome engineering.
In the current study, we investigated the role of this cholinergic signalling in object recognition using mice deficient for Vesicular Acetylcholine Transporter (VAChT) within interneurons of the striatum.
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CEO of Professional Science Editing for Scientists @ prosciediting.com