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They then compared their mouse data to genetic profiles of human lung tumors and found that reduced activity of the same gene, NKX2-1, is associated with higher death rates for lung-cancer patients.
Genotype and sex dependent differences in longevity have important implications for designing experiments with Alzheimer's mouse models, comparing genotype and sex differences in aging mouse models, designing drug treatment regimes and the translation of mouse data to human clinical studies.
After chronicling the different shifts of decomposers on the mice, and seeing the same shifts operating on the humans, the researchers built a computer model using the mouse data to see whether the microbial composition could be used to predict times of death, using the humans as a test case.
Several factors complicate the extrapolation of mouse data to the human situation.
When comparing the 15 components mouse data to the rat rsfMRI data, some striking differences were observed.
By filtering out the first principal component that represents expression differences between the species and/or platforms, will enable one with the remaining differences to translate mouse data to the human situation and vice versa, because species-specific variance in expression can be recognized and eliminated by subtraction.
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If not stated explicitly, we hereafter refer to mouse data and to the experiments in [ 2].
The individual mouse data added to Figure 2 figure supplement 2 and Figure 3 figure supplement 1 should help to clarify this and show the mouse-to-mouse variation.
The Tr values 0.80 and 0.90 that we determined from human and mouse data corresponded to R2 values 0.88 and 0.84, respectively.
The motivation for including mouse data is to get an evolutionary perspective.
The clinical and mouse data appear to be contradictory, but there is a possible explanation.
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