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This vast catalog of integrated biological information contains extensively curated mouse data that spans from DNA sequence to disease phenotype.
We are grateful for the use of the mouse data that was publicly available made by Jonathan Flint and Richard Mott from Welcome Trust Centre for Human Genetics.
Thus, we have conducted our analysis based on the human data, which is derived from mRNA and EST data, and the mouse data that is based on EST data, supported by our experimental data.
Additionally, in our mouse data that evaluated apoptosis against CD4+ T-cell and B-cell loss, only an indirect association of the contribution of BTLA expression to the apoptotic cell loss of CD4+ T cells and B cells could be drawn.
To better understand this lack of signal in the anterior horn, we examined our analogous G93A mouse data that used 3′ gene expression arrays and determined signal strength in the anterior horn and in motor neuron enriched mRNA pools isolated by microdissection using a similar bioinformatics analysis.
Even though it is desirable that vaccines for pandemic pathogens would provide protective immunity after a single administration, one cannot conclude from mouse data that a single injection with PELC-formulated H5N1 vaccine would be sufficient in humans.
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Moreover, we have recently found that PIHO disorders occur also in non-obese diabetic (NOD) and db/db mice (unpublished data) that are typical models representing for the main forms of diabetes in humans.
Only one, testing the effects of drugs on increased longevity of SOD1G934 mice, provides data that can be assessed, and even those data, obtained in an impressive manner, are presented in a review article.
3) The manuscript argues that the germ-free mouse data indicate that there is an endogenous antigen-driven selection program at work, but does not rule out food antigens as sources for this selection.
Celera officials say they did not rely on publicly available mouse data, arguing that this gives credence to their "whole-genome shotgun" strategy that relies on computer power more than DNA maps to work out the structure of genomes.
Mouse data suggest that in permissive strains, ES cells can be derived from embryos at around E4 E4.5 of development, a stage that has been termed the naive stage of embryogenesis (Nichols and Smith, 2009; Boroviak et al., 2014).
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