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Leu et al. [14] reported that topical AuNP application with epigallocatechin gallate and α-lipoic acid significantly accelerated mouse cutaneous wound healing through anti-inflammatory and antioxidation effects.
Mouse cutaneous wounding (two 6-mm wounds on the back) and stem cell implantation were carried out as described previously.
Moreover we observed that administration of a FbnE-enriched scaffold together with EPCs into mouse cutaneous wounds increases wound vascularization and consequent healing [ 54].
In the adult rat and mouse cutaneous tissue, mTOR immunoreactivity was found in a subset of primary sensory axons and in nonneuronal cells surrounding the peripheral axons in the dermis [ 44, 45].
Determination of (CD-1) mouse cutaneous RNA levels by real-time polymerase chain reaction showed transcripts arising from Cyp4f13 and 4f16(most abundant); Cyp4f18 and 4f39 (intermediate); Cyp4f14, 4f17, and 4f37 (low); and from Cyp4f15 and Cyp4f40 (highly variable or too low to measure in some animals) (Du et al. 2009).
Recently, it was demonstrated that a subset of sensory axons in adult rat and mouse cutaneous tissues contained an activated form the mammalian target of rapamycin, a serine/threonine protein kinase phosphorylated at serine 2448 (phospho-mTOR, P-mTOR) (Jimenez-Diaz et al., 2008; Geranton et al., 2009; Melemedjian et al., 2011; Obara et al., 2011a, 2011b; Verma et al., 2005).
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The obtained mAAFP was assayed in vivo in a mouse passive cutaneous anaphylaxis (PCA) model.
Furthermore, boiling water fraction from mycelium of P. linteus inhibited mouse triphasic cutaneous reaction [ 11].
The architecture of the skin was histologically identical between the wild-type (WT) and periostin-deficient mice before cutaneous wounding (data not shown).
Interestingly, immunization with P. papatasi SP15 protected mice from cutaneous leishmaniasis caused by Leishmania major [ 45].
Oura et al. [ 17] have observed the differences between PlGF deficient mice and wild-type mice in the cutaneous delayed-type hypersensitivity (DTH) reactions and found out that PlGF deficiency resulted in a diminished and abbreviated inflammatory response, together with a reduction of inflammatory angiogenesis and edema formation.
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