Therefore, the exaggerated Ca2+ influx through the abnormal AMPA receptors could be a therapeutic target for sporadic ALS, and the normalization of TDP-43 mislocalization in AR2 mice could serve as a reliable marker to evaluate the efficacy of newly developed treatments22.
Thus the GAD67-GFP BAC transgenic mice could serve as a valuable genetic tool for studying various processes of adult neurogenesis in the dentate gyrus.
Together with the selective innervation defects to the posterior crista, Slitrk6-KO mice could serve as a useful model to study the role of the semicircular canal in vestibular function.
The 129S2 mice could serve as model for primary progressive TB pathogenesis in susceptible human hosts.
Thus, HMGA2 transgenic mice could serve as a model for human maculopapular skin lesion.
The PLR pathway defect in Bst+/− mice could serve as a simple read-out for the efficacy of stem cell transplantation.
Some persisted more than 1 year, which suggests that even a few infected deer mice could serve as transseasonal reservoirs and mechanisms for over-winter virus maintenance.
With regard to the increasing tendency of various AWDs in neonates worldwide, our Dse null mice could serve as a model for human AWDs.
This result suggested that disruption of SSC function as a result of architectural changes in the postnatal niche is reversible and that the seAip1−/− mice could serve as a good model to study the underlying mechanisms.
