Exact(1)
Thus, reduction of dystrophin mRNA levels observed in the mdx mouse could result from aberrant splicing caused by the disruption of this splicing cis-element.
Similar(59)
JP Morgan analyst Kevin M. Kessel said that even though the sweetened bid won't change Vishay's financing needs, he remains "cautious that this game of cat-and-mouse could result in an even higher bid that would a) make already challenging financing even more so, and b) work against any potential synergy or accretion potential for VSH shareholders".
Given that initial brain influx would be expected to be the same in both mouse models, and differential retention of 18F-7B in transgenic mice could result from its binding to Aβ plaques and clearance of the unbound tracer as a function of time, we therefore used dynamic PET imaging over 1 to 75 min to interrogate regional localization of 18F-7B withen the brains of transgenic and WT mice.
The phenotype we observed in Ghsr-/ mice could result from GHS-R-mediated effects in central, peripheral and/or hormonal levels.
Therefore the low social interaction and USV emission of Asic3−/− ko) mice could result from the alteration of serotonin transmission in the hippocampus.
Given the importance of this muscle in breathing, a compromised diaphragm muscle in dt mice could result in inefficient oxygen intake leading to compensatory mechanisms from the cardiovascular system to maintain suitable oxygen saturation levels.
One possible explanation is that the lactation defect in this line of MMTV-Cre mice could result from the integration of the MMTV-Cre transgene into a gene critically important for mammary epithelial differentiation, secretory activation, or lactation.
From a practical perspective, differences in GTM profiles and metabolism within putatively isogenic mice could result in significant unforeseen variation in the effects of drug treatment in experimental animals and ultimately in humans.
The alteration in lymphocyte development and homeostasis in Lmna-/ mice could result from cell-intrinsic defects caused by Lmna gene deficiency, from the contribution of A-type lamin function in non-hematopoietic cells that impact lymphocyte development, or instead, from the severe pathology and poor health of the Lmna-/ mouse.
The increased growth rate of tumours in the bitransgenic mice could result from either increased proliferation, decreased apoptosis or both.
The phenotype we observed in Ghsr −/− mice could result from GHS-R mediated effects in central and/or peripheral sites.
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