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Right images are the PET and fDOT signals rendered to the envelope of the mouse corresponding to the sagittal (G), coronal (H) and axial (I) projections.
In addition, one mouse corresponding to the group treated with telmisartan did not develop any tumour.
This yielded 2616 up- and 2305 down-regulated MaSC signature probes in mouse, corresponding to 3410 unique gene symbols, of which 2754 had human orthologs.
Using our computational cross-species hybridization algorithms and the initial biologic experiment (Methods, 5% threshold CSH), we identified 4,259 commercial probes as cross-hybridizing (2,104 human, 2,155 mouse) corresponding to 3,550 distinct genes.
We identified a single major serine phosphorylation site in that study (S220 in the mouse, corresponding to S228 in the human protein) that was a substrate for MAP kinases both in intact cells and in cell-free systems.
In this context, NGR-mTNF showed a significant antitumour activity at very low doses (0.1 ng per mouse, corresponding to 5 ng per kg) (Curnis et al, 2000), equivalent in humans to a dose of 0.2 μg m−2, which was the selected starting dose for phase I clinical development.
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These absorbed doses were lower than the MTD of 25 MBq 213Bi-DOTA-AMBA in PC3-tumor-bearing mice, corresponding to the MTD at a mean absorbed dose of 4 Gy in the blood [31].
Copper and iron levels were significantly increased in brains of 12-week R6/2 HD mice, corresponding to late-stage HD.
12/15LO KO mice exhibited significantly greater insulin-stimulated skeletal muscle Akt phosphorylation after HFD, compared to WT mice, corresponding to their greater insulin sensitivity.
However, only iron was increased in the brains of 12-month CAG140 HD mice, corresponding to pre-clinical HD (Figures 4A D).
The level of Mmp13 mRNA was highly increased in MMTV-PyMT tumors after 7-weeks of age, with the highest levels found in older mice, corresponding to late stage tumors (Fig. 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com