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Neither virus replicated in the mouse cornea (data not shown).
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The twice daily dose of 40 and 20 mg kg−1 of A-285969 was chosen because pilot studies have shown A-285969 to be active in a mouse cornea model of angiogenesis at 50 mg kg−1 (Leal J and Bell R, unpublished data) and because doses of 20 mg kg−1 have shown to be safe on the gastrointestinal tract of dogs (Bell R in preparation).
Angiogenesis was elicited upon mouse cornea by chemical cautery with silver nitrate.
In vivo in a mouse cornea micropocket angiogenesis assay, PEG-QK hydrogels promoted more complete coverage of host microvasculature within the hydrogel.
The adult mouse cornea is comprised of three tissue layers: a surface of stratified epithelium, a collagenous stroma underneath and an inner endothelium.
The corneal assay is an in vivo model which consists in a neovascularization induced by burning the central area of mouse cornea [28].
Coverslips positioned on the mouse cornea were used as a contact glass.
Cover slips positioned on the mouse cornea were used as a contact glass.
The expression of VSX1 in human or mouse cornea remains unclear since many studies did not confirm the expression in cornea [ 234, 236, 237].
We also analyzed OMP2 expression in zebrafish cornea by in situ hybridization and detected no OMP2-positive signals in the cornea (data not shown).
X-ray patterns revealed vertical predominant directions for horse cornea while showing circumferential preferred orientations in pig and rabbit (Hayes et al. 2007) and horizontal directions in the mouse cornea (Sheppard et al. 2010).
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