For this reason, AIMP1-deficient mice contain cells with increased surface levels of gp96, thereby displaying the phenotypes similar to those of gp96tm transgenic mice [32].
Sections of pancreas stained with Insulin revealed that the islets of both p21-overexpressing transgenic and control mice contained cell debris and scattered nuclei, instead of stained living cells (Fig. 2D, STZ 1d), as previously reported [19], [20].
The field was changed in 1998, by a paper showing that the bone marrow of normal adult mice contains cells that can participate in skeletal muscle regeneration and give rise to new muscle fibre nuclei (Ferrari et al, 1998; Fig 2).
Smaller airways such as human bronchioli and mouse trachea contain cells with protruding apical region decorated with few microvilli, abundant smooth or rough (dependent on species) endoplasmic reticulum, and secretory granules smaller than those found in goblet cells (Pavelka et al. 1976; Plopper et al. 1980).
Aggregation of the blastomers from morula stage embryos of two disparate mouse lines results in the formation of a chimeric morula that develops into a mouse that contains cells from the two distinct parental backgrounds [ 8].
The testes from p53 knockout mice contain multinucleated cells resulting from primary spermatocytes that fail to undergo meiosis [ 18].
Inflammatory lesions in the salivary glands of MRL /lpr mice contain B cells producing IgA and IgM rheumatoid factor [ 32] and were, in addition, identified to be sites of IFNγ production [ 30].
Cellular isolates used for HSCT in mice contain, among other cells, stem cells and T cells.
Although the state of differentiation was not clear (for example, pluripotent versus multipotent), it was evident that the mouse mammary epithelium contained cells that were the progenitors of the tissue [ 9].
Based on this observation, the authors inferred that microglial progenitors must have originated in the YS, as this was the only site within the mouse embryo that contained cells with a macrophage phenotype before E8.0.
