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Furthermore, the present allometric scaling relation also predicts that one single stem cell is enough to maintain hematopoiesis for the entire lifespan of a mouse, consistent with published estimates [21].
Indeed, if we assume that a cell replicates 100 times before senescence, then the lifetime of a murine stem cell is longer than the lifetime of a mouse, consistent with the view [21] that a single stem cell may be enough to maintain hematopoiesis for the entire murine lifespan.
Endothelial cell sprouting is also reduced in tumor vessels in the NG2 null mouse, consistent with numerous studies demonstrating the importance of extracellular matrix attachment for activation of key signaling pathways in endothelial cells [ 46- 48].
The timing of both erasure and re-establishment of DNA methylation is later than that in the mouse, consistent with the longer gestation period in the rat (22 days in Wistar rats, compared to approximately 19 days in the mouse [ 53]).
Sialomucin (CD43) as well as CD62L is involved in monocyte migration into lymph nodes from the blood by HEVs, and our data would indicate that CD62L is not necessary or largely redundant in monocyte trafficking in the normal mouse, consistent with data from L-selectin deficient mice.
At the end of the regime, most p65FL mice developed outwardly growing typical papillomas with an average of three tumours per mouse, consistent with previous reports showing that C57BL/6 mice are relatively resistant to DMBA-/TPA-induced skin tumorigenesis (Abel et al, 2009).
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Focal narrowings in the coronary arteries were present in Sur2 mice consistent with vascular spasm.
CaIX staining was reduced in Hif1a+/− mice, consistent with a reduced HIF-1 response in these HIF-deficient mice.
In food-deprived mice the lipidation of LC3 was impaired and abundance of p62 increased in aorta of aged compared to young mice, consistent with dysfunctional autophagy induction.
Light-flicker treatment induced gamma oscillations and reduced Aβ levels in ageing wild-type mice, consistent with a physiological role for gamma stimulation in regulating Aβ metabolism.
Krt76 downregulation was first observed in hyperplastic oral epithelium (Fig. 5d; 13 out of 15 mice), consistent with the findings in human patients10.
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