Sentence examples for mouse colitis model from inspiring English sources
Efficacy study of CLX-103 in acute dextran sodium sulfate (DSS) mouse colitis model showed improved potency measured as Disease Activity Index (DAI) and histological scores in the colon as compared to sulfasalazine.
The current study was aimed at testing the efficacy of this GLP-1 nanomedicine in alleviating colonic inflammation and associated diarrhea in dextran sodium sulfate (DSS) induced mouse colitis model.
In this study, through structure-guided design, we engineered a single agent fusion of the IL-2 cytokine and JES6-1 Ab that, despite being covalently linked, preserves IL-2 exchange, selectively stimulating TReg expansion and exhibiting superior disease control to the mixed IL-2/JES6-1 complex in a mouse colitis model.
Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].
AJ performed animal experiments with a mouse colitis model, including in vitro analysis of tissue samples.
Aberrant histone modifications have received relatively limited attention, although they appear to occur more often and much earlier than aberrant DNA methylation in a mouse colitis model [ 27].
In three mouse colitis models, oral administration of Tpl/OxbCD NP notably mitigated manifestations relevant to colitis, and significantly suppressed expression of proinflammatory mediators, with the efficacy superior over free Tpl or a control nanomedicine based on poly(lactide-co-glycolide) (PLGA).
may therefore have a confounding effect in mouse colitis models, particularly as H. muridarum was shown to engage TLR2 and NOD1, both of which are expressed in intestinal epithelial cells [11], [23], [39], [40].
Therefore, the 17 strains have at least a prophylactic effect in mouse colitis models.
Furthermore the efficacy of IL-10 administration in mouse colitis models is contentious [ 36].
Considering that increased bead penetrability correlated with bacteria close to the epithelium in mouse colitis models, we asked whether this also translated to human patients with UC.
