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Badea, A; Johnson, GA; Williams, RW, Genetic dissection of the mouse CNS using magnetic resonance microscopy., Curr Opin Neurol, vol 22 no. 4 (2009), pp. 379-386 [abs1097/WCO.0b013e32832d9b86] [abs].
In addition, the pattern of immunoreactivity detected in the mouse CNS using the H120 anti-CRX antibody (retina and pineal) mirrors the pattern of CRX mRNA expression and not that of OTX1 and OTX2 mRNA expression as determined by in situ hybdridization (Fig. S1).
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Acetone swabs of control samples known to contain CN, tested positive for CN using the diphenylamine test.
Besides NFAT target genes or CRAC inhibitors, the Cn/NFAT pathway offers other possibilities for therapeutic intervention, for example, by direct targeting of Cn itself using Cn inhibitors such as cyclosporine A (CsA) or Tacrolimus (FK506).
A study of 115 cn/cn mice using linkage analysis mapped the cn locus to chromosome 4 with the natriuretic peptide receptor 2 (Npr2) gene as the primary candidate for the cn mutation.
Here, we assess how well various CN estimates in the same region can differentiate between two (unknown) CN states using the method described in Section 2.4.
Notably, any differences from the predicted CN states are not necessarily indicative of MDGA performance given that different mice were used for the microarray and ddPCR based determinations.
In 2004, the pharmacological effectiveness of CN was investigated using a mouse model of human mammary cancer.
This evaluation is done on the full-resolution CNs as well as smoothed CNs, where the CNs are smoothed by using non-overlapping bins for which the average of CNs is calculated.
CN was investigated using a Hidden Markov Model and CN Analyzer for Affymetrix GeneChip Mapping 250K arrays (CNAG 2.0) [39].
All mice used were males.
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