However, two of the "IL6LN" samples, expected to be pre-malignant, owing to the younger ages of these transgenic mice, clustered with the IL6PC samples in the PCT group and are marked with asterisks in Figure 1B.
We found the CDPs from tumor-bearing mice clustered closer with MDPs than did CDPs from tumor-free mice (Fig. 3d, Supplementary Tables 2, 3).
Scnn1b-Tg mice clustered tightly with their WT littermates at all ages.
The ABCG2s in human, mouse, lamprey, and zebrafish clustered with mouse ABCG3 in the other subclade.
In all cases with the mouse clusters the number of homologous genes is low (see Additional File 5) and few regulatory influences used for the model were identified as homologous, suggesting that these results should be taken as preliminary.
Nineteen novel mouse candidates were clustered with a known miRNA gene, lending strong support to the validity of those predictions.
In addition to the gender-based separation, a clear separation was observed between prednisolone-treated and vehicle-treated WT mice, whereas prednisolone-treated GRdim mice clustered closely together with vehicle-treated GRdim and WT mice (PC2).
Multiple lineages are likely to have contributed to this complex grouping; nine CTCs from the two KPC-mT/mG mice described above clustered with CTC-pro, characterized by abundant expression of Mki67 and an annotated cell-cycle signature (Whitfield et al., 2002).
We found that, even when housed within the same flexible film isolator, ASF mice clustered into two groups with some animals displaying hyper-IgE, whereas others were protected with undetectable IgE.
In contrast, the MMTV-Neu and MMTV-PyMT mouse models cluster with the human luminal breast cancer datasets only 42% out of 1,000 re-samplings with an IQR of 0.44 to 0.48 (range = 0.01 to0.01).
