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The cetacean aminograms formed a cluster that was markedly distinguishable from the mouse cluster, indicating that cetaceans and terrestrial mammals have quite different metabolic machinery for amino acids.
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Using deletion-reintroduction mouse models, they found that reintroduction of miR-19a/b rescued oncogenicity but not to the same extent as reintroduction of the entire cluster, indicating the pro-tumourigenic activity within this cluster.
Also in this analysis, the Pcd, L7-Pp2b and L7-∆γ2 mice largely formed their own clusters, indicating that they showed a unique phenotype on the Erasmus Ladder.
Cluster indicates the cluster number analyzed by k-means clustering (k = 30).
These genes are often clustered, indicating recent gene duplication events.
Clustering indicates high and separation low compositional similarity between the different mice.
Lower cluster numbers indicate clusters with more sequences included.
A total of 127 human clusters overlap with other human clusters, and 111 mouse clusters overlap with other mouse clusters.
Nevertheless, genes of cluster E were over-expressed in CM-S mice compared to CM-R mice indicating an interval between the response of CM-S and the response of CM-R mice.
In addition, PSA-NCAM-labelled neuronal progenitors are increased in the olfactory ventricle of m/m mice with progenitors appearing in tighter clusters relative to control mice, indicating a failure in disassociation from their homotypic chains (Fig. 3E H).
As shown in Fig. 1, aminograms of bottlenose dolphins, pacific white-sided dolphins, Risso's dolphins and false-killer whales formed a cetacean cluster that was markedly different from the cluster obtained from C57BL/6J and ICR mice, indicating that the physiological states of the cetaceans and the mice were markedly different.
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