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In testing microbicides for protective efficacy in a mouse chlamydia model [ 23], we found that chlorhexidine (CHX), a widely used microbicidal preservative, causes a 100-fold increase in vaginal susceptibility to Chlamydia trachomatis when tested three days after a single vaginal application of this surface-active agent.
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Shimada, K. et al. Caspase-1 dependent IL-1beta secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.
mouse challenge model (Fig. 2).
But here's the problem -- each mouse "model" is different and no single mouse "model" shows all the pathologic features of AD.
Chlamydia muridarum (MoPn) infection known to provide a strong protective immune response in the mouse model.
Previous immunological studies, mainly based on a C. muridarum intravaginal infection mouse model, have revealed that a Th1-dominant cell-mediated immunity is required for protection against Chlamydia urogenital tract infection [ 10- 12].
Mouse model of MDD.
M.P.C. and L.B.S. generated humanized mouse model.
A mouse model of familial hypertrophic cardiomyopathy.
xenograft mouse model [9].
The second strategy is using mouse model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com