The researchers first dissected two slivers of tissue spanning the entire depth of the mouse cerebral cortex – one from the visual cortex, measuring 450 x 350 x 54 micrometers (μm, or thousandths of a millimeter), and the other from the somatosensory cortex, measuring 500 x 1000 x 61 μm.
(I) Dot blotting was used to analyze the 5hmC level in P15 mouse cerebral cortex tissues.
The concentration of phenylalanine in mouse cerebral cortex was determined by liquid chromatography-tandem mass spectrometry.
The present study is the first to report that the mouse cerebral cortex is thicker in males than in females.
This study was designed to examine the effect of chronic alcohol intake on insulin signaling in mouse cerebral cortex.
Using this method, we studied populations of progenitor cells derived from the anterior and posterior embryonic mouse cerebral cortex, each growing in a standardized culture environment.
Thus, the design allowed assessment of the role of sex chromosome genes, independent of gonadal hormones, in the ontogeny of sex differences in the mouse cerebral cortex.
After 15 years, they predict that they will be able to observe the function of the zebrafish brain, or several areas from the mouse cerebral cortex.
5hmC level could be detected by spotting as much as 800 ng DNA in Neuro2a cells (Fig. 1H), compared to only 25 ng DNA in mouse cerebral cortex tissues (Fig. 1I).
Here, we show that when the N-cadherin gene had been conditionally deleted in the mouse cerebral cortex, the intra-cortical structures were nearly completely randomized; e.g., mitotic cells and postmitotic cells were scattered throughout the cortex without any order.
For example, TET1 deficiency in mice results in impaired neurogenesis and memory (Zhang et al., 2013; Kaas et al., 2013); knockdown of TET2 and TET3 in the mouse cerebral cortex leads to a block in neuronal differentiation (Hahn et al., 2013); TET3 is essential for early eye development in Xenopus (Xu et al., 2012).
