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Engraftment of transplanted human cells and co-localized host (mouse) cells participated in the formation of endothelium (Fig. 5C,5D).
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These data clearly show that both haematopoietic and non-haematopoietic cells participate to the pathogenesis of myocarditis in the Stat3C/C mice.
Th17 cells participate in renal damage, as demonstrated by an experimental study in mice showing that Th17 cell injection caused albuminuria and neutrophils infiltration in the kidney [ 57].
Submitting Cx3cr1 GFP/GFP Ccr2 +/RFP mice to the light-induced subretinal accumulation of MPs, we show that CCR2 expressing RFP+ cells participate in subretinal inflammation (Fig 5).
Exactly how new cells participate in information processing remains unclear.
The mice in the study were inoculated with human cells because mouse cells do not become infected with H.I.V.
conducted in vitro studies using mouse cells.
Mouse cells have a history of not always being a good model for human cells.
Dr. Yamanaka worked with mouse cells, and Dr. Thomson worked with human cells from foreskins.
Last year, Dr. Yamanaka published a paper showing that he could add four genes to mouse cells and turn them into mouse embryonic stem cells.
Most were grown on mouse cells, and there is always a risk that mouse viruses could contaminate the cells and harm any human who receives them.
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