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Previous work in cultured mouse cells indicated that rRNA is regulated by methylation of a single CpG dinucleotide at position −133 residing at the upstream control element (UCE) [31].
The data we obtained from mouse cells indicated that the defect in cohesion is specific to the centromere; therefore, we tested whether BAF180 is also important for mediating cohesion between telomeres.
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Similar results were obtained in mouse cells, indicating that USP52 has a conserved role in the hypoxia response (results not shown).
Positive results of MTT assay and DNA quantification L929 mouse fibroblast cells indicated that the scaffold made from the combination of natural polymer (gelatin) and synthetic polymer (PCL) may serve as a good candidate for tissue engineering applications.
Our analysis of mouse ES cells indicated a very low level of intragenic CpGi methylation.
Consistent with this notion, ChIP-Seq studies in mouse ES cells indicated that tagged H3.3 was associated not only with actively transcribed genes, but also with repressed and poised genes [ 3].
While studies in frog and chick embryos suggested that Wnt/β-catenin signaling suppressed cardiac differentiation, evidence from mouse P19CL6 teratocarcinoma cells indicated a positive role for Wnt/β-catenin signaling in cardiogenesis [10], [11], [12].
The addition of the SOLID dataset (derived from mouse ES cells) indicates that approximately 58% of all UCEs are transcribed in mouse, in line with the lower boundary indicated by the microarray of 40% and the higher boundary indicated by the PCR validations of 70%.
Studies have shown that p73 can regulate neural stem cell maintenance (Agostini et al., 2010), and the overexpression of transactivation-deficient p73 proteins resulted in the proliferation of human and mouse tumor cells, indicating oncogenic activity of truncated p73 isoforms (Stiewe et al., 2002).
Our experiments in cultured mouse tubular cells indicate that part of the apoptotic arrest is mediated via the inhibition of capspase 9 and caspase 3. Our ongoing studies in cultured monkey kidney cells (Butin-Israeli and Oppenheim, unpublished), using proteomics arrays, have indicated that VLPs activate PLCγ.
Comparing transcription factor expression in the bovine ICMs used in the microarray with known expressions in mouse pluripotent cells indicates a "primed" or epiblast state.
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