Loss of the Dmrt1 transcription factor in mouse Sertoli cells, even in adult mice, activates Foxl2 and reprograms Sertoli cells into granulosa cells.
It was demonstrated that p53 biosynthesis increases rapidly in response to IR in mouse 3T3 cells, even after treating the cells with the transcription inhibitor actinomycin D [ 6].
Compared with untreated resistant cells, the presence of TBN resulted in a ca. 100-fold higher R123 accumulation in mouse lymphoma cells, even at a low concentration, whereas the tylosin and the Betti-base showed only limited effect.
Compounds 1 7 were found to be non-toxic towards the normal mouse fibroblast (3T3) cells, even at the highest concentrations tested (100 μg/mL).
We hypothesized that relatively low frequency mechanical stimulation (0.01 Hz) can inhibit adipogenic differentiation of C3H10T1/2 mouse mesenchymal stem cells, even in a potent adipogenic differentiation medium.
In contrast, downregulation of Bcl-2 was detected in STAT5-deficient mice and bone marrow cells, even when stimulated with SCF and IL-3 [ 36, 37].
Later, it was demonstrated that these ES cells were able to contribute to the germ line in chimera mice derived from ES cells, even after genome modification by retrovirus [ 21, 22].
To investigate the status of the XCI and PCH-marks on the elephant and marsupial Xi, we conducted dual immunofluorescences with antibodies specific to six of these marks, in combination with H3K27me3 (Table 2, Figure 3) (NB: H2AK119ub and macroH2A were not analyzed because the antibodies available to us produced no consistent signal of enrichment, even in mouse cells).
We have now revised the text and cited Brambrink et al to note that a proportion of induced cells express Oct4 and Nanog, even in mouse cells.
Hu and colleagues indicated that β-catenin is essential for the survival and self-renewal of CML stem cells even in mice subjected to kinase inhibition therapy [ 7].
