In this regard, mouse cells differed markedly from human cells.
It is not known whether mouse and human cells differ in their SASPs, although senescent mouse cells were shown to secrete specific factors that can have systemic effects [29], [42].
The growth requirements of rat XEN-P and mouse XEN cells differed as well: In several independent plating experiments, XEN cells (line MX4) formed no colonies on Li1 cells that supported XEN-P (line RX1) colony growth, but grew well on primary mouse embryo fibroblast batches that failed to support XEN-P colony formation.
Furthermore, and despite some similarities, the cellular environment of human and mouse cells may differ in important aspects.
Previous publications demonstrated that mouse Th1 and Th17 cells differ in their susceptibility to apoptosis.
RNA expression data reveals that human embryonic stem (hES) cells differ from mouse ES (mES) cells in the expression of RNAs for keratin intermediate filament proteins.
Katsuta, H. et al. Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.
However we did find data on mass-specific metabolic rates [ 33, 34], from which we can estimate energy consumption per mouse cell by assuming that human and mouse cells do not differ greatly in mass.
Of note, not only the number but also the features of CD4+ T cells differed in PD-1 / PD-1 /comiceed with WT micompared
In addition, the reason for the species-specific effect of dexamethasone may be due to differences in the metabolism of dexamethasone between human and mouse cells, which results in differing major metabolites (Tomlinson et al, 1997).
