In agreement with our observations in the MMH-D3/HBV-Met mouse cell system, CDH13 mRNA was significantly enriched in HBV-positive specimens, but IGFBP3 also seemed to be slightly upregulated.
Recombinant mouse cytokines (Cell Systems, St. Katharinen, Germany) were added in the following concentrations: interleukin-3, interleukin-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF), 10 ng/ml; SCF, 100 ng/ml.
The mouse and cell systems described here are potential in vivo and in vitro models to assay pesticides, environmental chemicals, and pharmaceuticals as candidate contributors to PD by disrupting DOPAL detoxification.
To gain mechanistic insights on how Wnt10b regulates HMGA2 expression we turned to our previously published mouse cell line system NMuMG (NMG) and NMuMG -Wnt10b (NMG-10b; Miranda-Carboni et al, 2008).
We used normal and Hsf2-deficient mice and cell systems to uncover a pivotal role for heat shock factor 2 (HSF2) in radial neuronal migration defects in the cortex, a hallmark of fetal alcohol exposure.
In this study, we specifically investigated whether these SL molecules target the tumor promotion stage of tumorigenesis and cell transformation using the well-established JB6 mouse epidermal cell system, which includes the promotion-sensitive P + cells [ 18, 19].
HSF1 is the dominant HSF responsible for the HSR and cannot be replaced by any other HSF in mice or model cell systems.
To investigate the novel hypothesis that Rho activity regulates fascin-1, we used two cell systems: mouse C2C12 skeletal myoblasts and human SW480 colon carcinoma cells.
As shown in Fig. 4, the overexpression of ChoKα1 was sufficient to induce tumour growth in immunosuppressed mice in the both cell systems analyzed.
By using a mouse model and immune-competent cell systems, we studied the role of D2 in controlling the innate immune response.
