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The hyh mouse carrying a point mutation in the gene encoding for soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein alpha (α-SNAP) develops inherited hydrocephalus.
More detailed genetic studies showed that it was a house mouse carrying a big chunk of DNA from Algerian mice (Mus spretus)—a species known to be naturally resistant to warfarin on chromosome 7.
When the template DNA from a mouse carrying a CAG repeat of 111 was mixed with that of a mouse carrying a longer CAG repeat (Figure 1C; right-hand side of the gel), the longer of the two PCR products was clearly under-represented or, with the longest repeat sizes, undetectable.
The hyperphosphorylation of TAU in the retina of the mouse carrying a deletion of the Nxnl1 gene likely plays a role in the degeneration of rods observed in that model and in also in their sensitivity to oxidative stress [15].
6 8 week old male and female heterozygous Lrp1b mice were intercrossed (with each mouse carrying a different Lrp1b allele, such that homozygote embryos could be detected as those carrying both the Lrp1btm1wtsi and Lrp1btm2wtsi alleles).
To determine the role for Id1 in mammary development and neoplasia in vivo, we generated a mouse carrying a transgene encoding murine Id1 cDNA under the control of the modified tetracycline response element, TREtight (Clontech).
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A transgenic mouse carrying an Rps19 R62W mutation, which is common in DBA, has been recently developed (Devlin et al., 2010).
This mouse carries a loss-of-function mutation in the very low density lipoprotein receptor gene (Vldlr) [24].
The murine model for dystrophin mutations, the mdx mouse, carries a nonsense mutation in exon 23 (E23m) of the dystrophin gene.
The Apc min/+ mouse carries a germline mutation of the mouse adenomatous polyposis coli (Apc) gene.
In a 2006 study, researchers at Washington University, in St . Louis transferred gut microbes from mice carrying a mutation that caused them to be obese to mice lacking the mutation.
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