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This compound was metabolically stable in liver microsomes and displayed anti-tumor activity in xenograft mouse cancer models.
Lessons learned from investigating spontaneous mouse cancer models have important implications for directing clinical efforts that attempt to direct a cancer patient's immune system to eradicate their disease.
Since it was known copper was required for angiogenesis, TM was tested on mouse cancer models to see if it would inhibit tumor growth based on an antiangiogenic effect.
This model is well supported by in vivo genetic evidence in mouse cancer models.
Conclusively, systemic treatment with anti-uPA monoclonal antibody, mU1, was effective in delaying wound healing and may thus have a therapeutic potential in mouse cancer models.
Treatment with systemic IL-12 of mouse cancer models has been shown to have a strong anti-tumor effect [26], [27].
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To answer this question, we should study the regulation and function of TAZ extensively in cancer cells, especially using the mouse cancer model.
Ochoa et al. ablated IL-6 in a mouse cancer model and found that this markedly inhibited both the development of COPD-like lung inflammation and lung cancer [109].
Thus, a wild-type mouse cancer model must be used.
Limk2 deletion increased colon tumour size in a colitis-associated colorectal mouse cancer model.
Recently, cell surface B7-H1 has been demonstrated to play an anti-apoptotic role in a mouse cancer model [ 31].
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Justyna Jupowicz-Kozak
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