Sentence examples for mouse brains injected from inspiring English sources

Pre-existing intracranial U87 gliomas in nude mouse brains injected intratumorally with Muse-tk cells followed by intraperitoneal GCV administration were significantly reduced in size within 2 weeks, and 4 of 10 treated mice survived over 200 days.

In brief, sarkosyl-insoluble αsyn was prepared from WT mouse brains injected with recombinant αsyn fibrils and was injected into Str of other WT mouse brains.

IL-17A mRNA is not detectable in normal mouse brain or mouse brain injected with PBS.

In this study, we investigated the spread and distribution pattern of psyn pathology in mouse brain injected with recombinant αsyn fibrils into three different brain regions: SN, Str, and EC.

In vivo, Tau aggregates from P301S transgenic mice and human brains, injected into Alz17 mice (mouse strain overexpressing the longest Tau isoform), were captured/internalised by neurons at the IS.

Analysis of nTg mouse brains neonatally injected with 2 μg of exogenous fibrillar 21 140 αS and aged up to 8 months did not reveal the presence of any αS pathology (Table  1).

The editing efficiencies at these sites were not changed in the mouse brain area injected with AAV9-GFP.

AAV vectors expressing Cas9 and sgRNA targeting a single gene (Mecp2, which causes the neurodevelopmental disorder Rett syndrome), as well as multiple genes (Dnmt1, Dnmt3a and Dnmt3b from the DNA methyltransferase family), in adult mouse brains have been stereotactically injected into the dentate gyrus, enabling reverse genetic studies of gene function in the brain [ 34].

None of the injected mouse brains contained detectable levels of phosphorylated alpha-synuclein species that were insoluble in sarkosyl (Additional file 8) indicating that the intraneuronal inclusion bodies, which had accumulated over time, were not Lewy body-like but instead represented an early stage synucleinopathy that might precede Lewy body pathology.

This was performed on both the contralateral and ipsilateral slm of ChABC injected sections (7 mouse brains, 3 sections each), as well as vehicle injected sections (3 mouse brains, 3 sections each).

Cells engineered to produce an enzyme that dissolves Alzheimer's plaques worked when injected into mouse brains.