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Xenografts of fewer than 500 cells in Nude mouse brains induced a progressively growing tumor.
Recent studies revealed that intracerebral injection of recombinant α-synuclein fibrils into wild-type mouse brains induced prion-like propagation of hyperphosphorylated α-synuclein pathology.
Primary cells injected orthotopically into immune competent syngeneic mouse brains induced grade IV tumors within 2 to 3 weeks and recapitulated TRP GEM tumor histopathology, including its invasive properties.
TNFα has been shown to induce CXCL1 and CXCL2 in cultured mouse astrocytes and stereotaxic injection of TNF-α to the SJL and BALBc mouse brains induced CXCL2 [ 18, 42, 55].
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Luk et al. (2012 a ) showed that only inoculation of synthetic mouse α-synuclein fibrils into wild-type mouse brain induced synuclein pathology.
Administration of human recombinant ICAM-1 in BV2 cells and wild-type mice brains induced NEP expression in time- and dose-dependent manners.
Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions.
10.7554/eLife.00592.011 Figure 8. Native α-Syn purified from mouse brain induces v-vesicle clustering.
Neuronal loss in the adult mouse brain induces CNTF within hours [ 18] possibly by disinhibition of Thy-1.
Activation of constitutively active Notch4 in the blood vessels of the developing mouse brain induces vessel enlargement followed by hemorrhages in the cerebellum and the neocortex, neurological damage and death [ 86].
Recently, an interesting paper was published on the effect of estrogen exposure in mice brain, inducing an increment of the expression level of a discrete number of genes [ 53].
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