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Aβ deposits are associated with astro- and micro- gliosis, which was enhanced in APP/CCL2 bigenic mouse brains compared to APP mice (Fig. 4A L).
In this study, we did not detect significant changes in phosphorylation of Tyr705 in STAT3 and Ser473 in Akt, while phosphorylation of Thr308 in Akt was significantly increased in S14G-HN-treaed 3xTg-AD mouse brains compared with control (Fig. 9).
Increased exon inclusion for genes involved in neuronal development was also detected in E18 FUS−/− mouse brains compared with WT FUS brains (Rogelj et al., 2012).
Thresholding image analysis verified this widespread and significant microglial activation in the S1BF of Cln1/5 dko mouse brains, compared with wild-type mice (Fig. 3D).
In the present study, GM3 was slightly increased in double-Tg mouse brains compared with WT mouse brains (Table 1); the increase was statistically significant for GM3 in female double-Tg mouse brains.
Similarly, of the 174 SDEG involved in the proinflammatory response network, only 51 were up-regulated in the wild type-infected mouse brains, compared to 135 SDEG in the mutant- infected ones.
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The intracerebral cytokine balance was biased toward a Th1 profile in dying mouse brain compared with surviving mouse brain.
As shown in Figure 2H, there were more apoptotic cells (TUNEL-positive) in arrb1 −/− mouse brain compared with WT mice.
We found that the levels of NRF-1 and TFAM mRNA were reduced in mnd2 mouse brain compared with those in wide-type mouse brain.
Histology revealed that asarone treatment increased the number of BrdU/NeuN double-positive neurons in the mouse brain compared with that in vehicle-treated mice (Fig. 5G– J).
As shown in Figure 5d, intraperitoneal injection of Rib for 10 days led to an increase of AGE formation in the mouse brain compared with saline as control.
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